Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
| ▸ | STAT6 | P42226 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL8023146 | 1.00 | CA1 (0.35) | CA1CA9SMN1; SMN2MEN1KMT2A | |
| SCHEMBL439067 | 0.87 | CA1 (0.41) | CA1CA9SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2860232 | 0.87 | CA1 (0.41) | CA1CA9SMN1; SMN2MEN1KMT2A | |
| SCHEMBL15195848 | 0.87 | CA1 (0.41) | CA1CA9SMN1; SMN2MEN1KMT2A | |
| SCHEMBL682255 | 0.87 | CA1 (0.41) | CA1CA9SMN1; SMN2MEN1KMT2A | |
| Glycolic Acid SCHEMBL247101 | 0.85 | APEX1 (0.31) | CA1CA9LMNA | |
| Methane SCHEMBL1276943 | 0.84 | CA1 (0.39) | CA1CA9SMN1; SMN2MEN1KMT2A | |
| SCHEMBL15823554 | 0.84 | CA1 (0.39) | CA1CA9SMN1; SMN2MEN1KMT2A | |
| SCHEMBL16872863 | 0.84 | CA1 (0.39) | CA1CA9SMN1; SMN2MEN1KMT2A | |
| Ammonia Solution, Strong SCHEMBL17351919 | 0.84 | CA1 (0.39) | CA1CA9SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2083834-B1 | MACROCYCLIC LACTONE COMPOUNDS AND METHODS FOR THEIR USE | ELIXIR MEDICAL CORP (US) | 2017-06-21 | — | — | EP | claimed |
| CN-113881030-B | Low molecular weight carbon dioxide-cyclohexene oxide copolymer, preparation method thereof and epoxy-terminated polycyclohexene carbonate | 中国科学院长春应用化学研究所 | 2023-05-05 | — | — | CN | disclosed |
| CN-107531663-B | Method and apparatus for producing lactide | 荷兰普拉克公司 | 2022-02-08 | — | — | CN | disclosed |
| EP-3288930-B1 | METHOD AND DEVICE FOR MANUFACTURING LACTIDE | PURAC BIOCHEM BV (NL) | 2021-04-21 | — | — | EP | disclosed |
| US-10023553-B2 | Method and device for manufacturing lactide | PURAC BIOCHEM BV (NL) | 2018-07-17 | — | — | US | disclosed |
| US-20180155313-A1 | METHOD AND DEVICE FOR MANUFACTURING LACTIDE | PURAC BIOCHEM BV (NL) | 2018-06-07 | — | — | US | disclosed |
| EP-3288930-A1 | METHOD AND DEVICE FOR MANUFACTURING LACTIDE | PURAC Biochem BV (NL) | 2018-03-07 | — | — | EP | disclosed |
| CN-107531663-A | The method and apparatus for manufacturing lactide | 荷兰普拉克公司 | 2018-01-02 | — | — | CN | disclosed |
| US-20160339153-A1 | BIOABSORBABLE FIXATION DEVICES | SMITH & NEPHEW, INC. (US) | 2016-11-24 | — | — | US | disclosed |
| WO-2016174161-A1 | METHOD AND DEVICE FOR MANUFACTURING LACTIDE | PURAC BIOCHEM BV (NL) | 2016-11-03 | — | — | WO | disclosed |
| WO-2009064509-A1 | ANNULAR RING IMPLANT | SMITH & NEPHEW, INC. (US) | 2009-05-22 | — | — | WO | disclosed |
| EP-1804850-B1 | BIOABSORBABLE POLYMERS COMPRISING CALCIUM CARBONATE | SMITH & NEPHEW INC (US) | 2009-03-11 | — | — | EP | disclosed |
| US-20080119947-A1 | Annular Ring Implant | SMITH & NEPHEW, INC. (US) | 2008-05-22 | — | — | US | disclosed |
| WO-2008061216-A2 | ANNULAR RING IMPLANT | SMITH & NEPHEW, INC. (US) | 2008-05-22 | — | — | WO | disclosed |
| EP-1804850-A2 | BIOABSORBABLE POLYMERS COMPRISING CALCIUM CARBONATE | Smith and Nephew, Inc. (US) | 2007-07-11 | — | — | EP | disclosed |
| US-20060120994-A1 | Bioabsorbable polymers | SMITH & NEPHEW, INC. | 2006-06-08 | — | — | US | disclosed |
| WO-2006050119-A2 | BIOABSORBABLE POLYMERS COMPRISING CALCIUM CARBONATE | SMITH & NEPHEW, INC. (US) | 2006-05-11 | — | — | WO | disclosed |
| US-6713593-B2 | REACTING DELTA-VALEROLACTONE OR LACTIDE, CARBON DIOXIDE, AND ALKYLENE OXIDE WITH A CATALYST TO FORM A BIODEGRADEABLE POLYCARBONATE-CO-POLYLACTONE; USES GREENHOUSE GAS CARBON DIOXIDE AS RAW MATERIAL | POHANG IRON & STEEL CO., LTD. (KR) | 2004-03-30 | — | — | US | disclosed |
| US-20030013840-A1 | Copolymer comprising alkylene carbonate and method of preparing same | POHANG IRON & STEEL CO., LTD. (KR) | 2003-01-16 | — | — | US | disclosed |
| WO-2002031023-A1 | COPOLYMER COMPRISING ALKYLENE CARBONATE AND METHOD OF PREPARING SAME | POHANG IRON & STEEL CO., LTD. (KR) | 2002-04-18 | — | — | WO | disclosed |