Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 9/20 | 0.74 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.63 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.53 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.53 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.53 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.53 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.53 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.53 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | GPR183 | P32249 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3089444 | 0.91 | AKR1C3 (0.78) | AKR1C3HRH4GRIN2DGRIN3BGRIN1 | |
| SCHEMBL11981622 | 0.88 | AKR1C3 (0.84) | AKR1C3GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL13174666 | 0.87 | AKR1C3 (0.74) | AKR1C3HRH4GRIN2DGRIN3BGRIN1 | |
| SCHEMBL13174668 | 0.87 | AKR1C3 (0.74) | AKR1C3HRH4GRIN2DGRIN3BGRIN1 | |
| SCHEMBL3101848 | 0.85 | AKR1C3 (1.00) | AKR1C3HRH4GRIN2DGRIN3BGRIN1 | |
| SCHEMBL3099610 | 0.85 | AKR1C3 (0.85) | AKR1C3HRH4GRIN2DGRIN3BGRIN1 | |
| SCHEMBL13173599 | 0.83 | AKR1C3 (0.69) | AKR1C3HRH4GRIN2DGRIN3BGRIN1 | |
| SCHEMBL3106410 | 0.83 | AKR1C3 (0.72) | AKR1C3GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL13174677 | 0.82 | AKR1C3 (0.71) | AKR1C3GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL13174701 | 0.82 | AKR1C3 (0.71) | AKR1C3GRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010101127-A1 | INDOLE COMPOUND | アステラス製薬株式会社 (JP) | 2010-09-10 | — | — | WO | disclosed |