Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 13/20 | 0.51 |
| ▸ | STK4 | Q13043 | 4/20 | 0.43 |
| ▸ | MARK3 | P27448 | 2/20 | 0.42 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.42 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.41 |
| ▸ | PLK2 | Q9NYY3 | 2/20 | 0.41 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.41 |
| ▸ | TTK | P33981 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2396059 | 0.84 | PLK1 (0.59) | PLK1STK4MARK3MARK4PLK3 | |
| SCHEMBL2396937 | 0.84 | MARK3 (0.59) | PLK1STK4MARK3MARK4PLK3 | |
| SCHEMBL2395781 | 0.82 | PLK1 (0.59) | PLK1STK4MARK3MARK4PLK3 | |
| SCHEMBL1202832 | 0.82 | PLK1 (0.63) | PLK1STK4MARK3MARK4MAPK7 | |
| SCHEMBL2398574 | 0.81 | PLK1 (0.52) | PLK1STK4MARK3MARK4PLK3 | |
| SCHEMBL2395325 | 0.80 | PLK1 (0.66) | PLK1PLK3PLK2MAPK7DYRK1A | |
| SCHEMBL2398556 | 0.80 | PLK1 (0.59) | PLK1MARK3MARK4CCNE1CDK2 | |
| SCHEMBL2399284 | 0.80 | PLK1 (0.53) | PLK1STK4MARK3MARK4PLK3 | |
| SCHEMBL2397642 | 0.80 | PLK1 (0.54) | PLK1CCNE1CDK2TTK | |
| SCHEMBL2394298 | 0.79 | PLK1 (0.58) | PLK1STK4MARK3MAPK7DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1983987-B1 | DIHYDRODIAZEPINES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2010-09-01 | — | — | EP | disclosed |