Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 8/20 | 0.50 |
| ▸ | TAS2R8 | Q9NYW2 | 4/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13177530 | 0.88 | IGF1R (0.50) | IGF1RTAS2R8HDAC1HDAC6 | |
| SCHEMBL13177341 | 0.87 | IGF1R (0.49) | IGF1RTAS2R8HDAC1HDAC6 | |
| SCHEMBL2941564 | 0.81 | IGF1R (0.53) | IGF1RTAS2R8PPARGPPARDPPARA | |
| SCHEMBL13076385 | 0.78 | IGF1R (0.52) | IGF1RTAS2R8PPARGPPARDPPARA | |
| Trifluoroacetic Acid SCHEMBL19410373 | 0.76 | IGF1R (0.52) | IGF1RTAS2R8PPARGPPARDPPARA | |
| SCHEMBL13039129 | 0.74 | IGF1R (0.67) | IGF1RTAS2R8 | |
| SCHEMBL13177453 | 0.74 | IGF1R (0.57) | IGF1RTAS2R8 | |
| SCHEMBL4882177 | 0.73 | IGF1R (0.56) | IGF1RTAS2R8PPARGPPARDPPARA | |
| SCHEMBL4855706 | 0.72 | IGF1R (0.50) | IGF1RTAS2R8HDAC1HDAC6 | |
| SCHEMBL2935325 | 0.72 | IGF1R (0.53) | IGF1RTAS2R8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-B1 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA SA (FR) | 2010-09-22 | — | — | EP | disclosed |