Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.57 |
| ▸ | KDR | P35968 | 5/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13177413 | 0.91 | EGFR (0.61) | EGFRKDRERBB2LCK | |
| SCHEMBL13177534 | 0.87 | EGFR (0.52) | EGFRKDRERBB2LCK | |
| SCHEMBL13177415 | 0.84 | EGFR (0.58) | EGFRKDRERBB2LCK | |
| SCHEMBL13177539 | 0.81 | EGFR (0.41) | EGFRKDRERBB2LCK | |
| SCHEMBL13177576 | 0.80 | EGFR (0.55) | EGFRKDRERBB2LCK | |
| SCHEMBL13177571 | 0.79 | EGFR (0.54) | EGFRERBB2LCK | |
| SCHEMBL13177531 | 0.79 | EGFR (0.47) | EGFRKDRERBB2LCK | |
| SCHEMBL13709100 | 0.76 | EGFR (0.72) | EGFRKDRERBB2LCK | |
| SCHEMBL1219612 | 0.76 | EGFR (0.65) | EGFRKDRERBB2LCK | |
| SCHEMBL1219614 | 0.76 | EGFR (0.65) | EGFRKDRERBB2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773791-B1 | PYRROLOTRIAZINE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2010-09-22 | — | — | EP | disclosed |