Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 3/20 | 0.51 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.47 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.46 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.44 |
| ▸ | CDC42BPB | Q9Y5S2 | 3/20 | 0.44 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.44 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.44 |
| ▸ | PRKCB | P05771 | 1/20 | 0.44 |
| ▸ | PRKCA | P17252 | 1/20 | 0.44 |
| ▸ | PRKCH | P24723 | 1/20 | 0.44 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.43 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30503827 | 1.00 | MAP4K4 (0.51) | MAP4K4DOT1LPBKGPBAR1HRH4 | |
| SCHEMBL18239360 | 0.90 | HRH4 (0.54) | MAP4K4HRH4ROCK2ROCK1CDC42BPB | |
| SCHEMBL674099 | 0.90 | HRH4 (0.54) | MAP4K4HRH4ROCK2ROCK1CDC42BPB | |
| Hydrochloric Acid SCHEMBL673161 | 0.89 | HRH4 (0.52) | HRH4ROCK2ROCK1CDC42BPBPRKCQ | |
| Hydrochloric Acid SCHEMBL18228434 | 0.89 | HRH4 (0.52) | HRH4ROCK2ROCK1CDC42BPBPRKCQ | |
| SCHEMBL5912878 | 0.81 | MAP4K4 (0.50) | MAP4K4GPBAR1 | |
| SCHEMBL26972596 | 0.81 | MAP4K4 (0.50) | MAP4K4GPBAR1 | |
| SCHEMBL1381114 | 0.80 | HRH3 (0.58) | HRH4ROCK2ROCK1CDC42BPBCYP2D6 | |
| SCHEMBL29683665 | 0.79 | PRKCQ (0.53) | MAP4K4DOT1LPBKGPBAR1HRH4 | |
| SCHEMBL723065 | 0.79 | PRKCQ (0.53) | MAP4K4DOT1LPBKGPBAR1HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105837577-B | 1- (pyrimidine-4-yl) 3- aminopiperidine derivatives and its preparation method and application | 四川大学 | 2019-01-25 | — | — | CN | claimed |
| CN-105837577-A | 1-(pyrimidine-4-yl)-3-aminopiperdine derivative and its preparation method and use | 四川大学 | 2016-08-10 | — | — | CN | claimed |
| CN-116478163-A | Process for preparing (R) -N- (1- (9H-purin-6-yl) piperidin-3-yl) acrylamides | 成都赜灵生物医药科技有限公司 | 2023-07-25 | — | — | CN | disclosed |
| CN-105837577-B | 1- (pyrimidine-4-yl) 3- aminopiperidine derivatives and its preparation method and application | 四川大学 | 2019-01-25 | — | — | CN | disclosed |
| CN-105837577-B | 1- (pyrimidine-4-yl) 3- aminopiperidine derivatives and its preparation method and application | 四川大学 | 2019-01-25 | — | — | CN | disclosed |
| CN-105837577-B | 1- (pyrimidine-4-yl) 3- aminopiperidine derivatives and its preparation method and application | 四川大学 | 2019-01-25 | — | — | CN | disclosed |
| CN-105837577-A | 1-(pyrimidine-4-yl)-3-aminopiperdine derivative and its preparation method and use | 四川大学 | 2016-08-10 | — | — | CN | disclosed |
| CN-105837577-A | 1-(pyrimidine-4-yl)-3-aminopiperdine derivative and its preparation method and use | 四川大学 | 2016-08-10 | — | — | CN | disclosed |
| CN-105837577-A | 1-(pyrimidine-4-yl)-3-aminopiperdine derivative and its preparation method and use | 四川大学 | 2016-08-10 | — | — | CN | disclosed |
| EP-1796669-B1 | AMINOPIPERIDINES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK SHARP & DOHME (US) | 2010-09-22 | — | — | EP | disclosed |