Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13178205 | 0.80 | HDAC1 (0.49) | HDAC6HDAC1PIK3CAPIK3R1HDAC3 | |
| SCHEMBL1686124 | 0.76 | PIK3CA (0.55) | HDAC6HDAC1PIK3CAPIK3R1HDAC3 | |
| SCHEMBL1685944 | 0.74 | HDAC1 (0.53) | HDAC6HDAC1PIK3CAPIK3R1HDAC3 | |
| SCHEMBL1685770 | 0.72 | HDAC1 (0.54) | HDAC6HDAC1PIK3CAPIK3R1HDAC3 | |
| SCHEMBL1687289 | 0.72 | HDAC1 (0.52) | HDAC6HDAC1PIK3CAPIK3R1HDAC3 | |
| SCHEMBL10270092 | 0.70 | HDAC1 (0.63) | HDAC6HDAC1PIK3CAPIK3R1HDAC3 | |
| SCHEMBL1686530 | 0.70 | HDAC1 (0.51) | HDAC6HDAC1PIK3CAPIK3R1HDAC3 | |
| SCHEMBL1685965 | 0.70 | HDAC1 (0.50) | HDAC6HDAC1PIK3CAPIK3R1HDAC3 | |
| SCHEMBL1285145 | 0.67 | HDAC1 (0.59) | HDAC6HDAC1PIK3CAPIK3R1HDAC3 | |
| SCHEMBL1687433 | 0.66 | PIK3CA (0.52) | HDAC6HDAC1PIK3CAPIK3R1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100222343-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | CURIS, INC. | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222343-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | BAZ2A, BAZ2B, PI4KB | HDAC6 124/4885HDAC1 10/4885PIK3CA 58/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.