Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | BLM | P54132 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | PPARG | P37231 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.55 |
| ▸ | TGM2 | P21980 | 1/20 | 0.53 |
| ▸ | FPR2 | P25090 | 4/20 | 0.52 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | AVPR2 | P30518 | 4/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NPY4R | P50391 | 3/20 | 0.42 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL18617 | 0.95 | MEN1 (0.60) | MEN1BLMKMT2AUSP2POLB | |
| Hydrochloric Acid SCHEMBL30207638 | 0.95 | MEN1 (0.60) | MEN1BLMKMT2AUSP2POLB | |
| Hydrochloric Acid SCHEMBL29354092 | 0.95 | MEN1 (0.60) | MEN1BLMKMT2AUSP2POLB | |
| Hydrochloric Acid SCHEMBL10325011 | 0.94 | MEN1 (0.59) | MEN1BLMKMT2AUSP2POLB | |
| Hydrochloric Acid SCHEMBL31337069 | 0.94 | MEN1 (0.59) | MEN1BLMKMT2AUSP2POLB | |
| SCHEMBL3903552 | 0.94 | MEN1 (0.61) | MEN1BLMKMT2AUSP2POLB | |
| SCHEMBL29593395 | 0.94 | MEN1 (0.61) | MEN1BLMKMT2AUSP2POLB | |
| Perchlorate SCHEMBL31688153 | 0.91 | MEN1 (0.60) | MEN1BLMKMT2AUSP2POLB | |
| Acetic Acid SCHEMBL29510237 | 0.91 | MEN1 (0.60) | MEN1BLMKMT2AUSP2POLB | |
| Hydrochloric Acid SCHEMBL3506817 | 0.90 | MEN1 (0.60) | MEN1BLMKMT2AUSP2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8771642-B2 | Active particles for bio-analytical applications and methods for their preparation | Alma Mater Studiorum—Universita' di Bologna (IT) | 2014-07-08 | — | — | US | disclosed |
| US-20110274621-A1 | Active Particles for Bio-Analytical Applications and Methods for Their Preparation | ALMA MATER STUDIORUM-UNIVERSITA'DI BOLOGNA (IT) | 2011-11-10 | — | — | US | disclosed |
| EP-2328620-A2 | ACTIVE PARTICLES FOR BIO-ANALYTICAL APPLICATIONS AND METHODS FOR THEIR PREPARATION | Alma Mater Studiorum - Università di Bologna (IT) | 2011-06-08 | — | — | EP | disclosed |
| WO-2010013136-A2 | ACTIVE PARTICLES FOR BIO-ANALYTICAL APPLICATIONS AND METHODS FOR THEIR PREPARATION | ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA (IT) | 2010-02-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110274621-A1 | Active Particles for Bio-Analytical Applications and Methods for Their Preparation | PHOSPHO1, LIPA, ALG1 | MEN1 294/4885BLM 2780/4885KMT2A 3433/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.