Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.34 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | GCK | P35557 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13182026 | 0.68 | HTR2A (0.46) | HRH1HTR2AKCNH2CYP2D6SLC6A2 | |
| SCHEMBL2305115 | 0.67 | HRH1 (0.43) | HRH1HTR2AGCKCYP2D6SLC6A2 | |
| SCHEMBL7296446 | 0.65 | HRH1 (0.64) | HRH1HTR2AKCNH2CYP2D6SLC6A2 | |
| SCHEMBL158098 | 0.63 | HRH1 (1.00) | HRH1KMT2AHTR2AKCNH2CYP2D6 | |
| SCHEMBL2300341 | 0.62 | HRH1 (0.50) | HRH1HTR2ACYP2D6SLC6A2SLC6A4 | |
| Iodide SCHEMBL28361744 | 0.62 | HRH1 (0.95) | HRH1KMT2AHTR2AKCNH2CYP2D6 | |
| Bromide SCHEMBL28357929 | 0.62 | HRH1 (0.95) | HRH1KMT2AHTR2AKCNH2CYP2D6 | |
| Hydrochloric Acid SCHEMBL5011445 | 0.62 | HRH1 (0.95) | HRH1KMT2AHTR2AKCNH2CYP2D6 | |
| Ammonia Solution, Strong SCHEMBL3795841 | 0.62 | HRH1 (0.95) | HRH1KMT2AHTR2AKCNH2CYP2D6 | |
| SCHEMBL7296537 | 0.61 | HRH1 (0.75) | HRH1KMT2AHTR2ACYP2D6SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803830-B2 | 3-amino-1-arylpropyl indoles and AZA-substituted indoles and uses thereof | ROCHE PALO ALTO LLC (US) | 2010-09-28 | — | — | US | disclosed |
| US-20090099236-A1 | 3-Amino-1-arylpropyl indoles and AZA-substituted indoles and uses thereof | ROCHE PALO ALTO LLC | 2009-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099236-A1 | 3-Amino-1-arylpropyl indoles and AZA-substituted indoles and uses thereof | IDO1, RB1, AHR | HRH1 581/4885TDP1 1415/4885SCN3A 1287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.