Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 7/20 | 0.57 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.54 |
| ▸ | PRKDC | P78527 | 1/20 | 0.54 |
| ▸ | FYN | P06241 | 7/20 | 0.54 |
| ▸ | EGFR | P00533 | 5/20 | 0.53 |
| ▸ | LCK | P06239 | 3/20 | 0.53 |
| ▸ | JAK3 | P52333 | 3/20 | 0.53 |
| ▸ | BTK | Q06187 | 3/20 | 0.53 |
| ▸ | ITK | Q08881 | 3/20 | 0.53 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | LYN | P07948 | 2/20 | 0.47 |
| ▸ | BLK | P51451 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14471386 | 0.84 | PIK3CD (0.63) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL14472337 | 0.82 | HDAC1 (0.52) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL14471390 | 0.81 | SRC (0.53) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL15826973 | 0.79 | FYN (0.57) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL28468967 | 0.78 | BTK (0.65) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL14471387 | 0.77 | SRC (0.64) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL14471393 | 0.77 | SRC (0.73) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL15826974 | 0.77 | FYN (0.54) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL15826975 | 0.76 | FYN (0.68) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL14471400 | 0.76 | SRC (0.56) | SRCPIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7799753-B2 | Bisubstrate inhibitors of protein tyrosine kinases as therapeutic agents | Board of Governers for Higher Education (US) | 2010-09-21 | — | — | US | disclosed |