Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 15/20 | 0.79 |
| ▸ | MEN1 | O00255 | 10/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.79 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.79 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.79 |
| ▸ | PKM | P14618 | 5/20 | 0.79 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.79 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.79 |
| ▸ | THRB | P10828 | 2/20 | 0.79 |
| ▸ | MMP2 | P08253 | 1/20 | 0.79 |
| ▸ | PPARG | P37231 | 1/20 | 0.79 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.79 |
| ▸ | POLB | P06746 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.59 |
| ▸ | METAP1 | P53582 | 2/20 | 0.58 |
| ▸ | APP | P05067 | 6/20 | 0.54 |
| ▸ | SNCA | P37840 | 5/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13184632 | 0.90 | MAPT (0.81) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL13184661 | 0.89 | MAPT (0.79) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL29350119 | 0.88 | MAPT (1.00) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL13184630 | 0.88 | MAPT (1.00) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL12218050 | 0.84 | MEN1 (0.82) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL13184631 | 0.81 | MAPT (0.78) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL14713028 | 0.78 | MAPT (0.67) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL14712877 | 0.76 | MAPT (0.64) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL13164874 | 0.75 | MAPT (0.63) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL13164871 | 0.75 | MEN1 (1.00) | MAPTMEN1KMT2AALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100227853-A1 | INHIBITORS OF CYCLIC AMP PHOSPHODIESTERASES | TRUSTEES OF BOSTON COLLEGE (US) | 2010-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100227853-A1 | INHIBITORS OF CYCLIC AMP PHOSPHODIESTERASES | PDE7A, PDE4A, PDE4C | MAPT 3911/4885MEN1 1933/4885KMT2A 3298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.