Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.54 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13187687 | 0.87 | GRM2 (0.59) | GRM2HDAC6KDM4EALDH1A1HDAC1 | |
| SCHEMBL13188229 | 0.85 | DHODH (0.53) | DHODHGRM2CYP2C9CYP11B1MEN1 | |
| SCHEMBL13188766 | 0.74 | ABL1 (0.52) | DHODHCYP2C9HDAC6MEN1KMT2A | |
| SCHEMBL13187685 | 0.74 | HDAC6 (0.57) | HDAC6MKNK1MKNK2SMPD1HDAC3 | |
| SCHEMBL23542930 | 0.74 | DHODH (0.56) | DHODHCYP2C9CYP11B1MEN1KMT2A | |
| SCHEMBL28871330 | 0.73 | DHODH (0.66) | DHODHCYP2C9CYP11B1MEN1KMT2A | |
| SCHEMBL2114841 | 0.73 | GRM2 (0.61) | GRM2KDM4EALDH1A1 | |
| SCHEMBL1109339 | 0.72 | MKNK1 (0.73) | HDAC6MKNK1MKNK2GAASMPD1 | |
| SCHEMBL13187767 | 0.71 | HDAC6 (0.59) | HDAC6MKNK1MKNK2ALDH1A1SMPD1 | |
| SCHEMBL3184009 | 0.70 | GRM2 (0.81) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |