Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.56 |
| ▸ | PTPRA | P18433 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | ACLY | P53396 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10236798 | 0.96 | PTPN1 (0.52) | PTPN1PTPRA | |
| SCHEMBL13189572 | 0.96 | PTPN1 (0.52) | PTPN1PTPRA | |
| SCHEMBL13189575 | 0.95 | PTPN1 (0.51) | PTPN1PTPRAKDM4ENPSR1 | |
| SCHEMBL13189580 | 0.91 | PTPN1 (0.52) | PTPN1PTPRAKDM4ENPSR1 | |
| SCHEMBL10236797 | 0.89 | — | — | |
| SCHEMBL17226322 | 0.89 | — | — | |
| SCHEMBL17226355 | 0.88 | PTPN1 (0.49) | PTPN1PTPRAKDM4ENPSR1 | |
| SCHEMBL10236438 | 0.87 | PTPN1 (0.53) | PTPN1KDM4E | |
| SCHEMBL10237574 | 0.87 | — | — | |
| SCHEMBL13189574 | 0.86 | KDM4E (0.53) | PTPN1PTPRAKDM4ENPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403860-B1 | PHOSPHOTHIOPHENE AND PHOSPHOTHIAZOLE AS HCV POLYMERASE INHIBITORS | IDENIX PHARMACEUTICALS INC (US) | 2015-11-04 | — | — | EP | disclosed |
| WO-2010101967-A2 | PHOSPHOTHIOPHENE AND PHOSPHOTHIAZOLE HCV POLYMERASE INHIBITORS | IDENIX PHARMACEUTICALS, INC. (US) | 2010-09-10 | — | — | WO | disclosed |