Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 8/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2803338 | 0.92 | HRH4 (0.47) | HRH4HTR3AHTR1AADRA2AADRA2C | |
| SCHEMBL13190900 | 0.86 | HRH4 (0.48) | HRH4HTR3AHTR1AADRA2AADRA2C | |
| SCHEMBL13190898 | 0.84 | HRH4 (0.47) | HRH4HTR3AHTR1AADRA2AADRA2C | |
| SCHEMBL2807487 | 0.83 | HRH4 (0.44) | HRH4HTR3AHTR1AADRA2AADRA2C | |
| SCHEMBL2803664 | 0.83 | HRH4 (0.44) | HRH4HTR3AHTR1AADRA2AADRA2C | |
| SCHEMBL15365193 | 0.83 | HRH4 (0.44) | HRH4HTR3AHTR1AADRA2AADRA2C | |
| SCHEMBL15365191 | 0.83 | HRH4 (0.44) | HRH4HTR3AHTR1AADRA2AADRA2C | |
| SCHEMBL13190759 | 0.82 | HRH4 (0.50) | HRH4HTR3AHTR1AADRA2AADRA2C | |
| SCHEMBL2805008 | 0.79 | HRH4 (0.48) | HRH4HTR3AHTR1AADRA2AADRA2C | |
| SCHEMBL13190896 | 0.79 | HRH4 (0.53) | HRH4HTR3AHTR1AADRA2AADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010108059-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AS ANTAGONISTS OF THE HISTAMINE H4 RECEPTOR | INCYTE CORPORATION (US) | 2010-09-23 | — | — | WO | disclosed |