Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.81 |
| ▸ | AURKA | O14965 | 1/20 | 0.70 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.70 |
| ▸ | PTK2 | Q05397 | 17/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1466032 | 1.00 | LRRK2 (0.81) | LRRK2AURKAAURKBPTK2 | |
| SCHEMBL12826852 | 0.93 | LRRK2 (0.78) | LRRK2AURKAAURKBPTK2 | |
| SCHEMBL12826961 | 0.93 | LRRK2 (0.78) | LRRK2AURKAAURKBPTK2 | |
| SCHEMBL12826754 | 0.93 | LRRK2 (0.78) | LRRK2AURKAAURKBPTK2 | |
| SCHEMBL12826416 | 0.93 | LRRK2 (0.78) | LRRK2AURKAAURKBPTK2 | |
| SCHEMBL12826570 | 0.93 | LRRK2 (0.78) | LRRK2AURKAAURKBPTK2 | |
| SCHEMBL1466058 | 0.93 | LRRK2 (0.77) | LRRK2AURKAAURKBPTK2 | |
| SCHEMBL12826424 | 0.92 | LRRK2 (0.76) | LRRK2AURKAAURKBPTK2 | |
| SCHEMBL12826692 | 0.92 | LRRK2 (0.76) | LRRK2AURKAAURKBPTK2 | |
| SCHEMBL12826560 | 0.92 | LRRK2 (0.76) | LRRK2AURKAAURKBPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010106097-A1 | SUBSTITUTED PYRIMIDINES FOR THE TREATMENT OF CANCER | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-23 | — | — | WO | disclosed |