Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.81 |
| ▸ | PTK2 | Q05397 | 19/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1376283 | 0.91 | LRRK2 (0.80) | LRRK2PTK2 | |
| SCHEMBL7449659 | 0.90 | LRRK2 (1.00) | LRRK2PTK2 | |
| SCHEMBL20430649 | 0.87 | PTK2 (0.89) | PTK2 | |
| SCHEMBL12149371 | 0.87 | PTK2 (1.00) | LRRK2PTK2 | |
| SCHEMBL12656986 | 0.86 | LRRK2 (0.74) | LRRK2PTK2 | |
| SCHEMBL12656975 | 0.86 | LRRK2 (0.81) | LRRK2PTK2 | |
| SCHEMBL1373737 | 0.86 | PTK2 (0.90) | PTK2 | |
| SCHEMBL12149354 | 0.86 | PTK2 (1.00) | LRRK2PTK2 | |
| SCHEMBL12149270 | 0.86 | PTK2 (1.00) | PTK2 | |
| SCHEMBL15887558 | 0.85 | PTK2 (0.85) | PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408752-B1 | SUBSTITUTED PYRIMIDINES FOR THE TREATMENT OF CANCER | BOEHRINGER INGELHEIM INT (DE) | 2015-08-12 | — | — | EP | disclosed |
| WO-2010106097-A1 | SUBSTITUTED PYRIMIDINES FOR THE TREATMENT OF CANCER | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-23 | — | — | WO | disclosed |