Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 12/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 11/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 11/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 11/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13191812 | 0.96 | PIK3CA (0.44) | MAPK1LMNAMAPTALOX12HTT | |
| SCHEMBL12984573 | 0.88 | JAK2 (0.45) | MAPK1LMNAMAPTALOX12HTT | |
| SCHEMBL12979485 | 0.84 | PIK3CA (0.44) | MAPK1JAK2JAK1JAK3PIK3CA | |
| SCHEMBL12979504 | 0.83 | JAK2 (0.46) | MAPK1LMNAJAK2JAK1JAK3 | |
| SCHEMBL12979104 | 0.83 | MAPK1 (0.46) | MAPK1LMNAJAK2JAK1JAK3 | |
| SCHEMBL12979078 | 0.81 | JAK2 (0.44) | MAPK1LMNAMAPTALOX12HTT | |
| SCHEMBL12979785 | 0.81 | JAK2 (0.46) | MAPK1LMNAMAPTALOX12HTT | |
| SCHEMBL5441526 | 0.81 | JAK2 (0.55) | MAPK1LMNAMAPTALOX12HTT | |
| SCHEMBL12979017 | 0.80 | PIK3CA (0.44) | MAPK1LMNAJAK2JAK1JAK3 | |
| SCHEMBL5449743 | 0.80 | MAPK1 (0.61) | MAPK1LMNAJAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012136694-A1 | PYRIDOPYRAZINE DERIVATIVES AND THEIR USE | ÆTERNA ZENTARIS GMBH (DE) | 2012-10-11 | — | — | WO | disclosed |