SCHEMBL13192027

SCHEMBL13192027

BC1/C(=C\c2ccc(C#N)cc2)C(=O)c2ccccc21

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.42
CYP2C9 P11712 2/20 0.42
CYP2C19 P33261 2/20 0.42
DUSP1 P28562 1/20 0.42
DUSP6 Q16828 1/20 0.42
TP53 P04637 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2D6 P10635 1/20 0.42
HIF1A Q16665 1/20 0.42
CYP19A1 P11511 3/20 0.42
TDP1 Q9NUW8 1/20 0.39
NR1H3 Q13133 1/20 0.39
PLCG2 P16885 1/20 0.39
MAOB P27338 2/20 0.37
MAOA P21397 1/20 0.37
MIF P14174 1/20 0.36
NPSR1 Q6W5P4 2/20 0.36
LMNA P02545 2/20 0.36
MAPT P10636 2/20 0.35
ALDH1A1 P00352 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13191828 0.84 CYP1A2 (0.41) CYP1A2CYP2C9CYP2C19DUSP1DUSP6
SCHEMBL13191831 0.84 CYP1A2 (0.56) CYP1A2CYP2C9CYP2C19DUSP1DUSP6
SCHEMBL6986961 0.83 CYP19A1 (0.42) CYP1A2CYP2C9CYP2C19DUSP1DUSP6
SCHEMBL3706106 0.83 CYP19A1 (0.42) CYP1A2CYP2C9CYP2C19DUSP1DUSP6
SCHEMBL3706107 0.83 CYP19A1 (0.42) CYP1A2CYP2C9CYP2C19DUSP1DUSP6
SCHEMBL13191830 0.81 CYP1A2 (0.45) CYP1A2CYP2C9CYP2C19DUSP1DUSP6
SCHEMBL13192026 0.81 MAOB (0.46) CYP1A2CYP2C9CYP2C19DUSP1DUSP6
SCHEMBL13191829 0.78 NPSR1 (0.57) CYP1A2CYP2C9CYP2C19DUSP1DUSP6
SCHEMBL6987364 0.77 DUSP1 (0.77) CYP1A2CYP2C9CYP2C19DUSP1DUSP6
SCHEMBL13191827 0.75 IGF1R (0.40) CYP1A2CYP2C9CYP2C19DUSP1DUSP6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010108058-A2 SMALL MOLECULE INHIBITORS OF DUSP6 AND USES THEREFOR UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2010-09-23 WO disclosed