Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.52 |
| ▸ | MIF | P14174 | 1/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CYP27A1 | Q02318 | 1/20 | 0.42 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13192051 | 0.92 | MAOB (0.49) | MAOBMIFCYP19A1MAPTNPSR1 | |
| SCHEMBL6990493 | 0.84 | MAOB (0.52) | MAOBMIFCYP19A1MAPTNPSR1 | |
| SCHEMBL13191829 | 0.84 | NPSR1 (0.57) | MAOBCYP19A1MAPTNPSR1LMNA | |
| SCHEMBL13191831 | 0.78 | CYP1A2 (0.56) | MAOBMIFCYP19A1MAPTNPSR1 | |
| SCHEMBL6992183 | 0.78 | DUSP1 (0.70) | MAOBMIFCYP19A1MAPTNPSR1 | |
| SCHEMBL13191828 | 0.76 | CYP1A2 (0.41) | MAOBMIFCYP19A1MAPTNPSR1 | |
| SCHEMBL6990418 | 0.76 | MAOB (0.49) | MAOBMIFCYP19A1MAPTNPSR1 | |
| SCHEMBL13191830 | 0.71 | CYP1A2 (0.45) | MIFCYP19A1MAPTNPSR1ALDH1A1 | |
| SCHEMBL8796524 | 0.70 | MIF (0.56) | MAOBMIFCYP19A1MAPTCYP27A1 | |
| SCHEMBL6988351 | 0.70 | NPSR1 (0.57) | MAOBCYP19A1MAPTNPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010108058-A2 | SMALL MOLECULE INHIBITORS OF DUSP6 AND USES THEREFOR | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2010-09-23 | — | — | WO | disclosed |