Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.53 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.53 |
| ▸ | NAMPT | P43490 | 19/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13018584 | 0.84 | DPP8 (0.60) | DPP8DPP9NAMPT | |
| SCHEMBL17572894 | 0.82 | DPP8 (0.53) | DPP8DPP9NAMPT | |
| SCHEMBL15490032 | 0.81 | DPP8 (0.60) | DPP8DPP9NAMPT | |
| SCHEMBL21847864 | 0.80 | DPP8 (0.50) | DPP8DPP9NAMPT | |
| SCHEMBL8203594 | 0.80 | DPP8 (0.55) | DPP8DPP9NAMPT | |
| SCHEMBL29992618 | 0.80 | DPP8 (0.55) | DPP8DPP9NAMPT | |
| SCHEMBL3438648 | 0.79 | NOTUM (0.61) | DPP8DPP9NAMPT | |
| SCHEMBL27923200 | 0.79 | DPP8 (0.57) | DPP8DPP9NAMPT | |
| SCHEMBL22169249 | 0.79 | DPP8 (0.53) | DPP8DPP9NAMPT | |
| SCHEMBL25678375 | 0.79 | DPP8 (0.54) | DPP8DPP9NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2693882-B1 | SUBSTITUTED CYCLOPROPYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK SHARP & DOHME (US) | 2017-06-28 | — | — | EP | disclosed |
| WO-2012138845-A1 | SUBSTITUTED CYCLOPROPYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK SHARP & DOHME CORP. (US) | 2012-10-11 | — | — | WO | disclosed |