Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 14/20 | 0.52 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.36 |
| ▸ | GPR142 | Q7Z601 | 3/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12980306 | 1.00 | PIK3CA (0.52) | PIK3CACREBBPGPR142PRKDC | |
| SCHEMBL9612556 | 0.91 | PIK3CA (0.42) | PIK3CA | |
| SCHEMBL12980329 | 0.90 | PIK3CA (0.54) | PIK3CACREBBPGPR142PRKDC | |
| SCHEMBL6127285 | 0.88 | PIK3CA (0.52) | PIK3CACREBBPGPR142 | |
| SCHEMBL2725196 | 0.87 | PIK3CA (0.56) | PIK3CACREBBPGPR142 | |
| SCHEMBL2734423 | 0.85 | PIK3CA (0.54) | PIK3CACREBBPGPR142PRKDC | |
| SCHEMBL3788584 | 0.83 | PIK3CA (0.60) | PIK3CACREBBPGPR142 | |
| SCHEMBL7876625 | 0.83 | PIK3CA (0.56) | PIK3CACREBBPGPR142PRKDC | |
| SCHEMBL7858457 | 0.83 | PIK3CA (0.56) | PIK3CACREBBPGPR142PRKDC | |
| SCHEMBL2726195 | 0.83 | PIK3CA (0.57) | PIK3CACREBBPPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120258953-A1 | Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture | EXELIXIS, INC. (US) | 2012-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120258953-A1 | Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture | PIK3R1, PIK3R3, PIK3R2 | PIK3CA 13/4885CREBBP 230/4885GPR142 2679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.