Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK2 | Q13002 | 3/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10096234 | 0.96 | GRIK2 (0.44) | GRIK2GRIK1KDM4EALDH1A1MAPK1 | |
| SCHEMBL10096236 | 0.95 | GRIK2 (0.45) | GRIK2GRIK1KDM4EALDH1A1MAPK1 | |
| SCHEMBL10096233 | 0.90 | GRIK2 (0.36) | GRIK2GRIK1KDM4EALDH1A1MAPK1 | |
| SCHEMBL984912 | 0.89 | NPSR1 (0.36) | GRIK2GRIK1KDM4EALDH1A1MAPK1 | |
| SCHEMBL4795709 | 0.83 | GRIK2 (0.50) | GRIK2GRIK1KDM4EALDH1A1MAPK1 | |
| SCHEMBL10095252 | 0.82 | GRIK2 (0.60) | GRIK2GRIK1KDM4EALDH1A1MAPK1 | |
| SCHEMBL4795703 | 0.82 | GRIK2 (0.47) | GRIK2GRIK1KDM4EALDH1A1MAPK1 | |
| SCHEMBL13153366 | 0.81 | GRIK2 (0.44) | GRIK2GRIK1KDM4EALDH1A1MAPK1 | |
| SCHEMBL14467831 | 0.81 | GRIK2 (0.46) | GRIK2GRIK1KDM4EALDH1A1MAPK1 | |
| SCHEMBL12923068 | 0.81 | GRIK2 (0.46) | GRIK2GRIK1KDM4EALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781478-B2 | Methods for treating hepatitis C | PTC THERAPEUTICS, INC. (US) | 2010-08-24 | — | — | US | disclosed |
| US-7781478-B2 | Methods for treating hepatitis C | PTC THERAPEUTICS, INC. (US) | 2010-08-24 | — | — | US | disclosed |