Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 11/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 9/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.40 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13199012 | 1.00 | ADORA2A (0.42) | ADORA2AADORA1ADORA2BLMNAMAPT | |
| SCHEMBL13198986 | 0.78 | HTR2A (0.43) | ADORA2AADORA1ADORA2BHTR2AMAPK1 | |
| SCHEMBL2953665 | 0.77 | TDP1 (0.40) | MCHR1TRPV4 | |
| SCHEMBL13198993 | 0.76 | MAPT (0.45) | LMNAMAPTMAPK1 | |
| SCHEMBL13198971 | 0.75 | MAPT (0.42) | LMNAMAPTMAPK1 | |
| SCHEMBL13198806 | 0.75 | ROCK1 (0.44) | LMNAMAPTMCHR1 | |
| SCHEMBL13199002 | 0.75 | MAPT (0.45) | LMNAMAPTMCHR1MAPK1 | |
| SCHEMBL13199019 | 0.74 | MAPT (0.45) | LMNAMAPTMCHR1MAPK1 | |
| SCHEMBL3600029 | 0.73 | PDE4B (0.41) | — | |
| SCHEMBL13199008 | 0.73 | ROCK1 (0.45) | LMNAMAPTMAPK1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767681-B2 | 2-Carbamide-4-phenylthiazole derivatives, preparation thereof and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2010-08-03 | — | — | US | disclosed |
| US-7767681-B2 | 2-Carbamide-4-phenylthiazole derivatives, preparation thereof and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2010-08-03 | — | — | US | disclosed |