Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 9/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8403095 | 0.96 | TP53 (0.44) | TP53MAPTSMN1; SMN2SIRT1KIF11 | |
| SCHEMBL8403512 | 0.94 | TP53 (0.51) | TP53MAPTSMN1; SMN2SIRT1KIF11 | |
| SCHEMBL763454 | 0.92 | TP53 (0.44) | TP53MAPTSMN1; SMN2SIRT1KIF11 | |
| SCHEMBL8404306 | 0.89 | TP53 (0.46) | TP53MAPTSMN1; SMN2SIRT1KIF11 | |
| SCHEMBL8403566 | 0.89 | TP53 (0.47) | TP53MAPTSMN1; SMN2SIRT1KIF11 | |
| SCHEMBL764166 | 0.89 | TP53 (0.45) | TP53MAPTSMN1; SMN2KIF11POLB | |
| SCHEMBL9962258 | 0.89 | TP53 (0.47) | TP53MAPTSMN1; SMN2SIRT1KIF11 | |
| SCHEMBL8404298 | 0.87 | TP53 (0.43) | TP53MAPTSMN1; SMN2KIF11POLB | |
| SCHEMBL14236421 | 0.87 | TP53 (0.43) | TP53MAPTSMN1; SMN2KIF11POLB | |
| SCHEMBL763995 | 0.87 | TP53 (0.42) | TP53MAPTSMN1; SMN2SIRT1KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767689-B2 | Carboline derivatives useful in the treatment of cancer | PTC THERAPEUTICS, INC. (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767689-B2 | Carboline derivatives useful in the treatment of cancer | PTC THERAPEUTICS, INC. (US) | 2010-08-03 | — | — | US | disclosed |
| US-7601840-B2 | Carboline derivatives useful in the inhibition of angiogenesis | PTC THERAPEUTICS, INC. (US) | 2009-10-13 | — | — | US | disclosed |