Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 5/20 | 0.45 |
| ▸ | CTSL | P07711 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 2/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12590837 | 1.00 | ATM (0.52) | ATMCDC7DBF4CTSKCTSL | |
| SCHEMBL12590984 | 0.91 | ATM (0.54) | ATMCTSK | |
| SCHEMBL12590838 | 0.89 | ATM (0.56) | ATMCTSKCTSLSMN1; SMN2CTSS | |
| SCHEMBL2407133 | 0.85 | SYK (0.46) | ATMCTSLCTSS | |
| SCHEMBL12272036 | 0.81 | TDP1 (0.49) | ATMCDC7DBF4SMN1; SMN2 | |
| SCHEMBL13199743 | 0.78 | ATM (0.52) | ATMCTSKCTSLHSD17B10CTSS | |
| SCHEMBL12272599 | 0.78 | TDP1 (0.46) | CDC7DBF4SMN1; SMN2 | |
| SCHEMBL12590824 | 0.78 | SMN1; SMN2 (0.47) | CDC7DBF4SMN1; SMN2HSD17B10 | |
| SCHEMBL3338146 | 0.77 | ATM (0.58) | ATMCTSKCTSLSMN1; SMN2CTSS | |
| Hydrochloric Acid SCHEMBL2406001 | 0.77 | TDP1 (0.45) | CDC7DBF4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767687-B2 | Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as RAF kinase inhibitors | BIOGEN IDEC MA INC. (US) | 2010-08-03 | — | — | US | disclosed |