Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 9/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 3/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13200615 | 0.90 | FLT3 (0.62) | FLT3RETNTRK1RAF1 | |
| SCHEMBL13200041 | 0.90 | FLT3 (0.62) | FLT3RETEGFRNTRK1RAF1 | |
| SCHEMBL13200580 | 0.89 | FLT3 (0.72) | FLT3MEN1KMT2ARETEGFR | |
| SCHEMBL13200037 | 0.89 | FLT3 (0.73) | FLT3ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL13200131 | 0.88 | FLT3 (0.60) | FLT3RETEGFRNTRK1RAF1 | |
| SCHEMBL13234840 | 0.85 | FLT3 (0.80) | FLT3MEN1KMT2ARETNPC1 | |
| SCHEMBL13234696 | 0.85 | FLT3 (0.80) | FLT3MEN1KMT2ARETNPC1 | |
| SCHEMBL13200045 | 0.85 | TRPV1 (0.56) | FLT3RETNTRK1RAF1 | |
| SCHEMBL13200022 | 0.85 | FLT3 (0.56) | FLT3ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL13200558 | 0.84 | RAF1 (0.59) | FLT3RETEGFRNTRK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |