Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 7/20 | 0.66 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.55 |
| ▸ | RET | P07949 | 6/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 2/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13200219 | 0.89 | FLT3 (0.64) | FLT3ROCK1RETNPC1RAB9A | |
| SCHEMBL13200037 | 0.86 | FLT3 (0.73) | FLT3ROCK1RETNPC1RAB9A | |
| SCHEMBL13200580 | 0.84 | FLT3 (0.72) | FLT3ROCK1RETNPC1RAB9A | |
| SCHEMBL13200052 | 0.83 | FLT3 (0.75) | FLT3ROCK1RETNPC1RAB9A | |
| SCHEMBL13200702 | 0.83 | FLT3 (0.60) | FLT3ROCK1RETNPC1RAB9A | |
| SCHEMBL13200615 | 0.83 | FLT3 (0.62) | FLT3RETNTRK1RAF1CSF1R | |
| SCHEMBL13200168 | 0.82 | FLT3 (0.56) | FLT3ROCK1RETNPC1RAB9A | |
| SCHEMBL13200695 | 0.82 | RET (0.60) | FLT3ROCK1RETNPC1RAB9A | |
| SCHEMBL13200097 | 0.82 | FLT3 (0.59) | FLT3ROCK1RETNPC1RAB9A | |
| SCHEMBL13200153 | 0.82 | FLT3 (0.58) | FLT3ROCK1RETNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |