Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 13/20 | 0.62 |
| ▸ | LCK | P06239 | 12/20 | 0.62 |
| ▸ | KDR | P35968 | 10/20 | 0.59 |
| ▸ | ABL1 | P00519 | 3/20 | 0.51 |
| ▸ | BCR | P11274 | 3/20 | 0.51 |
| ▸ | KIT | P10721 | 5/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | INSR | P06213 | 1/20 | 0.44 |
| ▸ | FES | P07332 | 1/20 | 0.44 |
| ▸ | LYN | P07948 | 1/20 | 0.44 |
| ▸ | FGR | P09769 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | CSK | P41240 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.44 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.43 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2965417 | 0.88 | LCK (0.66) | TEKLCKKDRABL1BCR | |
| SCHEMBL13219915 | 0.87 | LCK (0.46) | TEKLCKKDRABL1KIT | |
| SCHEMBL13315425 | 0.87 | LCK (0.65) | TEKLCKKDRABL1BCR | |
| SCHEMBL2974084 | 0.87 | LCK (0.65) | TEKLCKKDRABL1BCR | |
| SCHEMBL2965527 | 0.86 | TEK (0.70) | TEKLCKKDRABL1BCR | |
| SCHEMBL2977313 | 0.81 | TEK (0.70) | TEKLCKKDRABL1BCR | |
| SCHEMBL2962918 | 0.81 | TEK (0.73) | TEKLCKKDRABL1BCR | |
| SCHEMBL2964117 | 0.79 | TEK (0.66) | TEKLCKKDRABL1BCR | |
| SCHEMBL2976292 | 0.79 | TEK (0.77) | TEKLCKKDRABL1BCR | |
| SCHEMBL13202027 | 0.79 | TEK (0.77) | TEKLCKKDRABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776869-B2 | Heteroaryl-substituted alkyne compounds and method of use | AMGEN INC. (US) | 2010-08-17 | — | — | US | disclosed |