Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 15/20 | 0.60 |
| ▸ | TEK | Q02763 | 14/20 | 0.60 |
| ▸ | KDR | P35968 | 12/20 | 0.60 |
| ▸ | KIT | P10721 | 2/20 | 0.57 |
| ▸ | JAK2 | O60674 | 1/20 | 0.57 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.57 |
| ▸ | INSR | P06213 | 1/20 | 0.57 |
| ▸ | FES | P07332 | 1/20 | 0.57 |
| ▸ | LYN | P07948 | 1/20 | 0.57 |
| ▸ | FGR | P09769 | 1/20 | 0.57 |
| ▸ | JAK1 | P23458 | 1/20 | 0.57 |
| ▸ | CSK | P41240 | 1/20 | 0.57 |
| ▸ | JAK3 | P52333 | 1/20 | 0.57 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.57 |
| ▸ | MTOR | P42345 | 2/20 | 0.43 |
| ▸ | WDR5 | P61964 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2974807 | 1.00 | LCK (0.60) | LCKTEKKDRKITJAK2 | |
| SCHEMBL2967751 | 1.00 | LCK (0.60) | LCKTEKKDRKITJAK2 | |
| SCHEMBL2960989 | 0.92 | LCK (0.70) | LCKTEKKDRKITJAK2 | |
| SCHEMBL2965445 | 0.92 | LCK (0.70) | LCKTEKKDRKITJAK2 | |
| SCHEMBL13202032 | 0.92 | LCK (0.70) | LCKTEKKDRKITJAK2 | |
| SCHEMBL2966352 | 0.87 | LCK (0.72) | LCKTEKKDRKITJAK2 | |
| SCHEMBL13349377 | 0.86 | LCK (0.50) | LCKTEKKDRKITJAK2 | |
| SCHEMBL13349312 | 0.86 | LCK (0.50) | LCKTEKKDRKITJAK2 | |
| SCHEMBL13219917 | 0.86 | LCK (0.50) | LCKTEKKDRKITJAK2 | |
| SCHEMBL2965653 | 0.85 | TEK (0.59) | LCKTEKKDRKITJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776869-B2 | Heteroaryl-substituted alkyne compounds and method of use | AMGEN INC. (US) | 2010-08-17 | — | — | US | disclosed |