Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 8/20 | 0.51 |
| ▸ | TP53 | P04637 | 4/20 | 0.42 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8204539 | 1.00 | MDM2 (0.51) | MDM2TP53HTRA1CTSKCTSL | |
| SCHEMBL1319273 | 0.89 | MDM2 (0.52) | MDM2TP53CTSKCTSLCTSS | |
| SCHEMBL1319275 | 0.89 | MDM2 (0.52) | MDM2TP53CTSKCTSLCTSS | |
| SCHEMBL1319498 | 0.87 | MDM2 (0.56) | MDM2TP53HTRA1PGRMAPK1 | |
| SCHEMBL1319494 | 0.87 | MDM2 (0.56) | MDM2TP53HTRA1PGRMAPK1 | |
| SCHEMBL1319358 | 0.85 | MDM2 (0.54) | MDM2TP53PGRMAPK1 | |
| SCHEMBL1319363 | 0.85 | MDM2 (0.54) | MDM2TP53PGRMAPK1 | |
| SCHEMBL8211308 | 0.85 | MDM2 (0.50) | MDM2TP53 | |
| SCHEMBL1322112 | 0.84 | MDM2 (0.49) | MDM2TP53HTRA1TSHRMAPT | |
| SCHEMBL1322107 | 0.84 | MDM2 (0.49) | MDM2TP53HTRA1TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8058269-B2 | rac-6-chloro-3-(3-chloro-benzyl)-3-(3-isopropoxy-phenylamino)-1,3-dihydro-indol-2-one; murine double minute (MDM2 ) oncogene inhibitor; feedback control loop of p53 mutant cells; inhibit the interaction between p53 and MDM2 proteins | HOFFMAN-LA ROCHE INC. (US) | 2011-11-15 | — | — | US | claimed |
| EP-2066318-B1 | OXINDOLE DERIVATIVES AS ANTICANCER AGENTS | HOFFMANN LA ROCHE (CH) | 2010-05-12 | — | — | EP | claimed |
| US-8058269-B2 | rac-6-chloro-3-(3-chloro-benzyl)-3-(3-isopropoxy-phenylamino)-1,3-dihydro-indol-2-one; murine double minute (MDM2 ) oncogene inhibitor; feedback control loop of p53 mutant cells; inhibit the interaction between p53 and MDM2 proteins | HOFFMAN-LA ROCHE INC. (US) | 2011-11-15 | — | — | US | disclosed |