Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | RAB9A | P51151 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | BCHE | P06276 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | CTSL | P07711 | 1/20 | 0.51 |
| ▸ | CTSB | P07858 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1320762 | 1.00 | NPC1 (0.61) | NPC1MAPTRAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL31233027 | 0.86 | NPC1 (0.70) | NPC1MAPTRAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL1322133 | 0.86 | NPC1 (0.70) | NPC1MAPTRAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL1322132 | 0.86 | NPC1 (0.70) | NPC1MAPTRAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL1064874 | 0.82 | KMT2A (0.51) | MAPTALDH1A1SMN1; SMN2KMT2AABCG2 | |
| SCHEMBL1064876 | 0.82 | KMT2A (0.51) | MAPTALDH1A1SMN1; SMN2KMT2AABCG2 | |
| SCHEMBL1321492 | 0.82 | NPC1 (0.65) | NPC1MAPTRAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL1321491 | 0.82 | NPC1 (0.65) | NPC1MAPTRAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL1321476 | 0.81 | HDAC3 (0.67) | NPC1MAPTRAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL1320561 | 0.81 | HDAC3 (0.67) | NPC1MAPTRAB9AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814850-B9 | NEW HISTONE DEACETYLASES INHIBITORS | DAC SRL (IT) | 2015-02-25 | — | — | EP | disclosed |
| EP-1814850-B1 | NEW HISTONE DEACETYLASES INHIBITORS | DAC SRL (IT) | 2013-07-03 | — | — | EP | disclosed |
| US-8058273-B2 | Histone deacetylases inhibitors | DAC S.R.L. (IT) | 2011-11-15 | — | — | US | disclosed |
| US-7803800-B2 | Histone deacetylases inhibitors | DAC S.R.L. (IT) | 2010-09-28 | — | — | US | disclosed |
| US-20100240660-A1 | NEW HISTONE DEACETYLASES INHIBITORS | DAC S.R.L. (IT) | 2010-09-23 | — | — | US | disclosed |
| US-20080096889-A1 | Histone Deacetylases Inhibitors | GENEXTRA S.P.A. (IT) | 2008-04-24 | — | — | US | disclosed |
| EP-1814850-A1 | NEW HISTONE DEACETYLASES INHIBITORS | DAC S.R.L. (IT) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006037761-A1 | NEW HISTONE DEACETYLASES INHIBITORS | DAC S.R.L. (IT) | 2006-04-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240660-A1 | NEW HISTONE DEACETYLASES INHIBITORS | HDAC1, HDAC3, HDAC11 | NPC1 2600/4885MAPT 3303/4885RAB9A 2735/4885 |
| US-20080096889-A1 | Histone Deacetylases Inhibitors | HDAC1, HDAC3, HDAC11 | NPC1 2434/4885MAPT 3192/4885RAB9A 2918/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.