Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.63 |
| ▸ | FLT3 | P36888 | 8/20 | 0.63 |
| ▸ | KIT | P10721 | 8/20 | 0.63 |
| ▸ | FLT1 | P17948 | 7/20 | 0.58 |
| ▸ | CSF1R | P07333 | 6/20 | 0.58 |
| ▸ | FLT4 | P35916 | 6/20 | 0.58 |
| ▸ | LCK | P06239 | 5/20 | 0.58 |
| ▸ | LYN | P07948 | 4/20 | 0.58 |
| ▸ | BLK | P51451 | 4/20 | 0.58 |
| ▸ | FYN | P06241 | 3/20 | 0.58 |
| ▸ | ABL1 | P00519 | 2/20 | 0.58 |
| ▸ | SRC | P12931 | 2/20 | 0.58 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.57 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.57 |
| ▸ | NTRK2 | Q16620 | 4/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.57 |
| ▸ | RET | P07949 | 2/20 | 0.57 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.57 |
| ▸ | LTK | P29376 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5337990 | 0.84 | KDR (0.73) | KDRFLT3KITFLT1CSF1R | |
| Hydrochloric Acid SCHEMBL3959214 | 0.83 | KDR (0.72) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL3960218 | 0.82 | KDR (0.67) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL1322551 | 0.81 | FLT3 (0.48) | KDRFLT3KITFLT1CSF1R | |
| Hydrochloric Acid SCHEMBL3957794 | 0.81 | KDR (0.66) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL1323850 | 0.80 | KDR (0.53) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL1703063 | 0.79 | KDR (0.77) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL421901 | 0.79 | KDR (0.80) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL4722549 | 0.79 | FLT3 (0.52) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL2816436 | 0.78 | KDR (0.67) | KDRFLT3KITFLT1CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912988-B1 | 7-SUBSTITUTED AZA-INDAZOLES, COMPOSITIONS CONTAINING SAME, PRODUCTION METHOD AND USE THEREOF | AVENTIS PHARMA SA (FR) | 2014-04-16 | — | — | EP | claimed |
| US-8058290-B2 | E.g., 1-[4-(3-amino-1H-pyrazolo[3,4-b]pyridin-6-yl)phenyl]-3-(2-fluoro-5-trifluoromethylphenyl)urea; and N-(6-{4-[3-(2-fluoro-5-trifluoromethylphenyl)ureido]-phenyl}-1H-pyrazolo[3,4-b]pyridin-3-yl))thiophene-3-carboxamide; kinase inhibitors, anticancer agents | AVENTIS PHARMA S.A. (FR) | 2011-11-15 | — | — | US | claimed |
| CN-101304998-A | Substituted 7-aza-indazoles, compositions containing same, method for producing same and use thereof | AVENTIS PHARMA SA (FR) | 2008-11-12 | — | — | CN | claimed |
| US-20080182844-A1 | 7-Substituted Aza-Indazoles, Compositions Containing Same, Production Method and Use Thereof | AVENTIS PHARMA S.A. (FR) | 2008-07-31 | — | — | US | claimed |
| EP-1912988-A1 | 7-SUBSTITUTED AZA-INDAZOLES, COMPOSITIONS CONTAINING SAME, PRODUCTION METHOD AND USE THEREOF | Aventis Pharma S.A. (FR) | 2008-04-23 | — | — | EP | claimed |
| WO-2007017577-A1 | 7-SUBSTITUTED AZA-INDAZOLES, COMPOSITIONS CONTAINING SAME, PRODUCTION METHOD AND USE THEREOF | AVENTIS PHARMA S.A. (FR) | 2007-02-15 | — | — | WO | claimed |
| EP-1912988-B1 | 7-SUBSTITUTED AZA-INDAZOLES, COMPOSITIONS CONTAINING SAME, PRODUCTION METHOD AND USE THEREOF | AVENTIS PHARMA SA (FR) | 2014-04-16 | — | — | EP | disclosed |
| EP-1912988-B1 | 7-SUBSTITUTED AZA-INDAZOLES, COMPOSITIONS CONTAINING SAME, PRODUCTION METHOD AND USE THEREOF | AVENTIS PHARMA SA (FR) | 2014-04-16 | — | — | EP | disclosed |
| CN-101304998-B | Substituted 7-aza-indazoles, compositions containing same, method for producing same and use thereof | AVENTIS PHARMA SA | 2012-09-05 | — | — | CN | disclosed |
| US-8058290-B2 | E.g., 1-[4-(3-amino-1H-pyrazolo[3,4-b]pyridin-6-yl)phenyl]-3-(2-fluoro-5-trifluoromethylphenyl)urea; and N-(6-{4-[3-(2-fluoro-5-trifluoromethylphenyl)ureido]-phenyl}-1H-pyrazolo[3,4-b]pyridin-3-yl))thiophene-3-carboxamide; kinase inhibitors, anticancer agents | AVENTIS PHARMA S.A. (FR) | 2011-11-15 | — | — | US | disclosed |
| US-8058290-B2 | E.g., 1-[4-(3-amino-1H-pyrazolo[3,4-b]pyridin-6-yl)phenyl]-3-(2-fluoro-5-trifluoromethylphenyl)urea; and N-(6-{4-[3-(2-fluoro-5-trifluoromethylphenyl)ureido]-phenyl}-1H-pyrazolo[3,4-b]pyridin-3-yl))thiophene-3-carboxamide; kinase inhibitors, anticancer agents | AVENTIS PHARMA S.A. (FR) | 2011-11-15 | — | — | US | disclosed |
| US-8058290-B2 | E.g., 1-[4-(3-amino-1H-pyrazolo[3,4-b]pyridin-6-yl)phenyl]-3-(2-fluoro-5-trifluoromethylphenyl)urea; and N-(6-{4-[3-(2-fluoro-5-trifluoromethylphenyl)ureido]-phenyl}-1H-pyrazolo[3,4-b]pyridin-3-yl))thiophene-3-carboxamide; kinase inhibitors, anticancer agents | AVENTIS PHARMA S.A. (FR) | 2011-11-15 | — | — | US | disclosed |
| CN-102093353-A | 7-substituted aza-indazoles, compositions containing same, production method and use thereof | AVENTIS PHARMA SA | 2011-06-15 | — | — | CN | disclosed |
| CN-101304998-A | Substituted 7-aza-indazoles, compositions containing same, method for producing same and use thereof | AVENTIS PHARMA SA (FR) | 2008-11-12 | — | — | CN | disclosed |
| US-20080182844-A1 | 7-Substituted Aza-Indazoles, Compositions Containing Same, Production Method and Use Thereof | AVENTIS PHARMA S.A. (FR) | 2008-07-31 | — | — | US | disclosed |
| US-20080182844-A1 | 7-Substituted Aza-Indazoles, Compositions Containing Same, Production Method and Use Thereof | AVENTIS PHARMA S.A. (FR) | 2008-07-31 | — | — | US | disclosed |
| US-20080182844-A1 | 7-Substituted Aza-Indazoles, Compositions Containing Same, Production Method and Use Thereof | AVENTIS PHARMA S.A. (FR) | 2008-07-31 | — | — | US | disclosed |
| EP-1912988-A1 | 7-SUBSTITUTED AZA-INDAZOLES, COMPOSITIONS CONTAINING SAME, PRODUCTION METHOD AND USE THEREOF | Aventis Pharma S.A. (FR) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007017577-A1 | 7-SUBSTITUTED AZA-INDAZOLES, COMPOSITIONS CONTAINING SAME, PRODUCTION METHOD AND USE THEREOF | AVENTIS PHARMA S.A. (FR) | 2007-02-15 | — | — | WO | disclosed |
| WO-2007017577-A1 | 7-SUBSTITUTED AZA-INDAZOLES, COMPOSITIONS CONTAINING SAME, PRODUCTION METHOD AND USE THEREOF | AVENTIS PHARMA S.A. (FR) | 2007-02-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080182844-A1 | 7-Substituted Aza-Indazoles, Compositions Containing Same, Production Method and Use Thereof | PRMT7, PRKACA, PRKX | KDR 3171/4885FLT3 525/4885KIT 187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.