Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 10/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 5/20 | 0.41 |
| ▸ | DRD3 | P35462 | 5/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2908998 | 0.89 | EPHX2 (0.64) | EPHX2CYP2C9CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL2906841 | 0.86 | EPHX2 (0.52) | EPHX2CYP2C9CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL2908742 | 0.86 | EPHX2 (0.44) | EPHX2CYP2C9CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL13239535 | 0.82 | EPHX2 (0.60) | EPHX2CYP2C9CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL3036291 | 0.82 | EPHX2 (0.62) | EPHX2CYP2C9CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL3025646 | 0.80 | EPHX2 (0.51) | EPHX2CYP2C9CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL13218685 | 0.80 | SCN9A (0.48) | EPHX2CYP2C9CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL2904563 | 0.79 | EPHX2 (0.62) | EPHX2CYP2C9CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL13218640 | 0.77 | EPHX2 (0.76) | EPHX2CYP2C9CYP3A4CYP2D6CYP2C19 | |
| Trifluoroacetic Acid SCHEMBL3035769 | 0.77 | SCN9A (0.45) | EPHX2CYP2C9CYP3A4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100210655-A1 | NOVEL sEH INHIBITORS AND THEIR USE | GLAXOSMITHKLINE LLC | 2010-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100210655-A1 | NOVEL sEH INHIBITORS AND THEIR USE | EPHX1, NCEH1, FAH | EPHX2 5/4885CYP2C9 157/4885CYP3A4 158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.