Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 7/20 | 0.70 |
| ▸ | CDK9 | P50750 | 5/20 | 0.70 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.70 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.70 |
| ▸ | RET | P07949 | 9/20 | 0.60 |
| ▸ | CCNB2 | O95067 | 7/20 | 0.60 |
| ▸ | CDK1 | P06493 | 7/20 | 0.60 |
| ▸ | CCNB1 | P14635 | 7/20 | 0.60 |
| ▸ | CCNB3 | Q8WWL7 | 7/20 | 0.60 |
| ▸ | CDC7 | O00311 | 4/20 | 0.60 |
| ▸ | PRKACA | P17612 | 4/20 | 0.60 |
| ▸ | GSK3B | P49841 | 4/20 | 0.60 |
| ▸ | HIPK2 | Q9H2X6 | 4/20 | 0.60 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.60 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.60 |
| ▸ | PIM1 | P11309 | 3/20 | 0.59 |
| ▸ | CDK7 | P50613 | 1/20 | 0.59 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1044957 | 0.84 | CDC7 (0.69) | CDK2CDK9CCNT1CCNA2RET | |
| SCHEMBL8939628 | 0.84 | CDK2 (0.69) | CDK2CDK9CCNT1CCNA2RET | |
| SCHEMBL13239582 | 0.80 | CCNB2 (0.71) | CDK2CDK9CCNT1CCNA2RET | |
| SCHEMBL1668583 | 0.80 | CDK2 (0.80) | CDK2CDK9CCNT1CCNA2RET | |
| SCHEMBL15172141 | 0.79 | CDK2 (0.68) | CDK2CDK9CCNT1CCNA2RET | |
| SCHEMBL12572866 | 0.78 | CDK2 (0.61) | CDK2CDK9CCNT1CCNA2RET | |
| SCHEMBL15172140 | 0.78 | CDK2 (0.70) | CDK2CDK9CCNT1CCNA2RET | |
| SCHEMBL2534119 | 0.77 | CDC7 (0.68) | CDK2CDK9CCNT1CCNA2CDC7 | |
| SCHEMBL3250044 | 0.77 | CDK1 (0.59) | CDK2RETCCNB2CDK1CCNB1 | |
| SCHEMBL3776459 | 0.77 | CDK1 (0.77) | CDK2CDK9CCNT1CCNA2RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100173923-A1 | 4 (PYRROLOPYRIDINYL)PYRIMIDINYL-2-AMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-07-08 | — | — | US | disclosed |
| US-20100173923-A1 | 4 (PYRROLOPYRIDINYL)PYRIMIDINYL-2-AMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-07-08 | — | — | US | disclosed |
| WO-2007107221-A1 | 4-(PYRROLOPYRIDINYL)PYRIMIDINYL-2-AMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2007-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173923-A1 | 4 (PYRROLOPYRIDINYL)PYRIMIDINYL-2-AMINE DERIVATIVES | MKI67, CDK4, CCNT1 | CDK2 4/4885CDK9 52/4885CCNT1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.