Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.82 |
| ▸ | MAPK8 | P45983 | 10/20 | 0.82 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.82 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.82 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.82 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.82 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.82 |
| ▸ | NLK | Q9UBE8 | 2/20 | 0.82 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.82 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.63 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.63 |
| ▸ | GAK | O14976 | 1/20 | 0.62 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.62 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.62 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.62 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.62 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.62 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pamapimod SCHEMBL29429421 | 0.90 | MAPK14 (1.00) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| Pamapimod SCHEMBL29379723 | 0.90 | MAPK14 (1.00) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| Pamapimod SCHEMBL3636701 | 0.90 | MAPK14 (1.00) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| SCHEMBL14014497 | 0.88 | MAPK14 (0.79) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| SCHEMBL13239772 | 0.86 | MAPK14 (0.93) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| SCHEMBL2943312 | 0.86 | MAPK14 (0.64) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| SCHEMBL2943315 | 0.86 | MAPK14 (0.64) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| SCHEMBL14014670 | 0.86 | MAPK14 (0.88) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| SCHEMBL13239789 | 0.86 | MAPK14 (1.00) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| SCHEMBL13239775 | 0.83 | MAPK14 (0.84) | MAPK14MAPK8MAPK11MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7750016-B2 | Hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones | ROCHE PALO ALTO LLC (US) | 2010-07-06 | — | — | US | disclosed |
| US-7750016-B2 | Hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones | ROCHE PALO ALTO LLC (US) | 2010-07-06 | — | — | US | disclosed |
| US-20080119497-A1 | Hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones | ROCHE PALO ALTO LLC | 2008-05-22 | — | — | US | disclosed |
| US-20080119497-A1 | Hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones | ROCHE PALO ALTO LLC | 2008-05-22 | — | — | US | disclosed |
| US-7348331-B2 | Hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones | ROCHE PALO ALTO LLC (US) | 2008-03-25 | — | — | US | disclosed |
| US-7348331-B2 | Hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones | ROCHE PALO ALTO LLC (US) | 2008-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119497-A1 | Hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones | MAPK1, MAPK7, MAPK6 | MAPK14 39/4885MAPK8 7/4885MAPK11 42/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.