Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.43 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.42 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.42 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.42 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1324399 | 1.00 | CYP1A2 (0.46) | CYP1A2LMNARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL1323451 | 0.95 | CYP1A2 (0.49) | CYP1A2LMNARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL1324735 | 0.95 | CYP1A2 (0.49) | CYP1A2LMNARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL1323598 | 0.95 | CYP1A2 (0.49) | CYP1A2LMNARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL1323452 | 0.95 | CYP1A2 (0.49) | CYP1A2LMNARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL1324751 | 0.85 | HDAC2 (0.53) | CYP1A2LMNARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL1324636 | 0.85 | CA12 (0.49) | LMNAPOLBTRPA1SLC5A1SLC5A2 | |
| SCHEMBL1324753 | 0.85 | HDAC2 (0.53) | CYP1A2LMNARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL1324278 | 0.85 | HDAC1 (0.39) | LMNAKMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL1324281 | 0.85 | HDAC1 (0.39) | LMNAKMT2AHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8058313-B2 | 4-((1E)-2-(((E)-2-fluoro-4-cyanostyrylsulfonyl)methylsulfonyl)vinyl)-3-fluoro-benzonitrile; mitogen activated protein kinase inhibitor; cell growth factor receptor antagonist; angiogenesis inhibitor, antiproliferative and anticarcinogenic agent; neurodegenerative diseases | Temple University—Of the Commonwealth System of Higher Education (US) | 2011-11-15 | — | — | US | claimed |