Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.48 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13267203 | 0.86 | MAPT (0.44) | MAPTGAAEPHX1ALDH1A1L3MBTL1 | |
| SCHEMBL13244233 | 0.84 | MAPT (0.45) | MAPTGAAEPHX1ALDH1A1L3MBTL1 | |
| SCHEMBL10401177 | 0.78 | GAA (0.54) | MAPTGAAALDH1A1KDM4EKMT2A | |
| SCHEMBL7343322 | 0.77 | PLK1 (0.44) | MAPTALDH1A1L3MBTL1PLK1KMT2A | |
| SCHEMBL13244236 | 0.76 | MAPT (0.54) | MAPTGAAALDH1A1KDM4EKMT2A | |
| SCHEMBL7372599 | 0.76 | GAA (0.55) | MAPTGAAALDH1A1KDM4EKMT2A | |
| SCHEMBL16071443 | 0.76 | EPHX1 (0.76) | MAPTGAAEPHX1KCNMA1ALDH1A1 | |
| SCHEMBL7376464 | 0.76 | MYC (0.52) | MAPTGAAALDH1A1KDM4EKMT2A | |
| SCHEMBL9066391 | 0.75 | GAA (0.58) | GAATSHRSMN1; SMN2 | |
| SCHEMBL4340430 | 0.74 | HDAC3 (0.57) | MAPTGAAALDH1A1L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8338422-B2 | Indolin-2-ones and aza-indolin-2-ones | JANSSEN PHARMACEUTICA NV (BE) | 2012-12-25 | — | — | US | disclosed |
| US-20100190786-A1 | INDOLIN-2-ONES AND AZA-INDOLIN-2-ONES | JANSSEN PHARMACEUTICA NV (BE) | 2010-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190786-A1 | INDOLIN-2-ONES AND AZA-INDOLIN-2-ONES | IDO2, IDO1, MKI67 | MAPT 4356/4885GAA 2285/4885EPHX1 3609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.