Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 0.77 |
| ▸ | TNKS | O95271 | 3/20 | 0.39 |
| ▸ | PARP1 | P09874 | 3/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11981777 | 0.94 | JAK2 (0.72) | JAK2TNKSPARP1TNKS2 | |
| SCHEMBL2864688 | 0.93 | JAK2 (0.76) | JAK2TNKSPARP1TNKS2 | |
| SCHEMBL2861980 | 0.91 | JAK2 (0.73) | JAK2TNKSPARP1TNKS2 | |
| SCHEMBL13249645 | 0.91 | JAK2 (0.70) | JAK2TNKSPARP1TNKS2 | |
| SCHEMBL13249648 | 0.91 | JAK2 (0.70) | JAK2TNKSPARP1TNKS2 | |
| SCHEMBL13249650 | 0.90 | JAK2 (0.67) | JAK2TNKSPARP1TNKS2 | |
| SCHEMBL13249150 | 0.89 | JAK2 (0.71) | JAK2TNKSPARP1TNKS2 | |
| SCHEMBL13248941 | 0.89 | JAK2 (0.70) | JAK2 | |
| SCHEMBL13248939 | 0.87 | JAK2 (0.70) | JAK2TNKSPARP1TNKS2 | |
| SCHEMBL2871526 | 0.87 | JAK2 (1.00) | JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8349865-B2 | Inhibitors of janus kinases | MERCK SHARP & DOHME CORP. (US) | 2013-01-08 | — | — | US | disclosed |
| US-20100197634-A1 | INHIBITORS OF JANUS KINASES | MERCK SHARP & DOHME LLC | 2010-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197634-A1 | INHIBITORS OF JANUS KINASES | JAK2, JAK3, JAK1 | JAK2 1/4885TNKS 747/4885PARP1 1376/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.