Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.47 |
| ▸ | FLT1 | P17948 | 4/20 | 0.47 |
| ▸ | FLT4 | P35916 | 3/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | MAP2K7 | O14733 | 3/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1325194 | 0.90 | KDR (0.59) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL12124670 | 0.90 | MAP2K7 (0.46) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL1325203 | 0.89 | KDR (0.52) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL1325254 | 0.89 | KDR (0.59) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL1324088 | 0.87 | KDR (0.49) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL1325333 | 0.82 | MAOB (0.42) | KDRMAP2K7MAOBALDH1A1MAPT | |
| SCHEMBL4304598 | 0.81 | MAP2K7 (0.41) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL12124669 | 0.79 | KDR (0.56) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL1325204 | 0.79 | KDR (0.40) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL1324951 | 0.79 | NR2E1 (0.52) | KDRFLT1FLT4RETPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8058276-B2 | Heterobicyclic carboxamides as inhibitors for kinases | NOVARTIS AG (CH) | 2011-11-15 | — | — | US | disclosed |