Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.51 |
| ▸ | FLT1 | P17948 | 2/20 | 0.51 |
| ▸ | FLT4 | P35916 | 2/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1325272 | 0.90 | KDR (0.61) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL12124577 | 0.87 | KDR (0.56) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL1323962 | 0.86 | KDR (0.51) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL1325188 | 0.85 | KDR (0.56) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL1324117 | 0.84 | KDR (0.63) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL1324830 | 0.84 | KDR (0.54) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL1324954 | 0.84 | KDR (0.73) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL4548725 | 0.83 | KDR (0.71) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL1324859 | 0.82 | KDR (0.75) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL1325273 | 0.82 | KDR (0.51) | KDRFLT1FLT4RETPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8058276-B2 | Heterobicyclic carboxamides as inhibitors for kinases | NOVARTIS AG (CH) | 2011-11-15 | — | — | US | disclosed |