Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.51 |
| ▸ | FLT1 | P17948 | 2/20 | 0.49 |
| ▸ | FLT4 | P35916 | 2/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LOX | P28300 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12124590 | 0.88 | KDR (0.56) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL1325273 | 0.86 | KDR (0.51) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL1324066 | 0.85 | KDR (0.56) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL1324816 | 0.85 | KDR (0.52) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL1323861 | 0.83 | KDR (0.54) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL1325274 | 0.83 | KDR (0.63) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2435244 | 0.83 | KDR (0.71) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL1325055 | 0.83 | KDR (0.60) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL1325005 | 0.82 | KDR (0.61) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL1324209 | 0.81 | KDR (0.75) | KDRFLT1FLT4RETPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8058276-B2 | Heterobicyclic carboxamides as inhibitors for kinases | NOVARTIS AG (CH) | 2011-11-15 | — | — | US | claimed |
| US-8058276-B2 | Heterobicyclic carboxamides as inhibitors for kinases | NOVARTIS AG (CH) | 2011-11-15 | — | — | US | disclosed |