Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 13/20 | 0.65 |
| ▸ | JAK3 | P52333 | 11/20 | 0.65 |
| ▸ | JAK1 | P23458 | 8/20 | 0.65 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | SYK | P43405 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13253725 | 0.91 | JAK2 (0.63) | JAK2JAK3JAK1HDAC1HDAC6 | |
| SCHEMBL13253727 | 0.90 | JAK2 (0.59) | JAK2JAK3JAK1HDAC1HDAC6 | |
| SCHEMBL2866901 | 0.90 | JAK2 (0.81) | JAK2JAK3JAK1HDAC1 | |
| SCHEMBL30051224 | 0.90 | JAK2 (0.81) | JAK2JAK3JAK1HDAC1 | |
| SCHEMBL13253275 | 0.89 | JAK2 (0.81) | JAK2JAK3JAK1HDAC1HDAC6 | |
| SCHEMBL13253264 | 0.88 | JAK2 (0.60) | JAK2JAK3JAK1HDAC1HDAC6 | |
| SCHEMBL2863402 | 0.81 | JAK2 (0.79) | JAK2JAK3JAK1HDAC1 | |
| SCHEMBL30051760 | 0.81 | JAK2 (0.79) | JAK2JAK3JAK1HDAC1 | |
| SCHEMBL23897397 | 0.81 | JAK2 (0.78) | JAK2JAK3JAK1HDAC1 | |
| SCHEMBL2863080 | 0.80 | JAK2 (0.74) | JAK2JAK3JAK1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100197671-A1 | PHENYL AMINO PYRIMIDINE COMPOUNDS AND USES THEREOF | GLAXOSMITHKLINE LLC | 2010-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197671-A1 | PHENYL AMINO PYRIMIDINE COMPOUNDS AND USES THEREOF | JAK2, JAK1, JAK3 | JAK2 1/4885JAK3 3/4885JAK1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.