Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.65 |
| ▸ | JAK3 | P52333 | 15/20 | 0.65 |
| ▸ | JAK1 | P23458 | 12/20 | 0.65 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.63 |
| ▸ | TYK2 | P29597 | 2/20 | 0.63 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.63 |
| ▸ | PLK4 | O00444 | 1/20 | 0.63 |
| ▸ | CIT | O14578 | 1/20 | 0.63 |
| ▸ | GAK | O14976 | 1/20 | 0.63 |
| ▸ | OPA1 | O60313 | 1/20 | 0.63 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.63 |
| ▸ | STK16 | O75716 | 1/20 | 0.63 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.63 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.63 |
| ▸ | CDK2 | P24941 | 1/20 | 0.63 |
| ▸ | MARK3 | P27448 | 1/20 | 0.63 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.63 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.63 |
| ▸ | STAT3 | P40763 | 1/20 | 0.63 |
| ▸ | STAT5A | P42229 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13253312 | 0.90 | JAK2 (0.80) | JAK2JAK3JAK1HDAC1TYK2 | |
| SCHEMBL13253183 | 0.89 | JAK2 (0.79) | JAK2JAK3JAK1HDAC1TYK2 | |
| SCHEMBL13226402 | 0.88 | JAK2 (0.84) | JAK2JAK3JAK1HDAC1TYK2 | |
| SCHEMBL13253724 | 0.88 | JAK2 (0.79) | JAK2JAK3JAK1HDAC1TYK2 | |
| SCHEMBL13253313 | 0.86 | JAK2 (0.67) | JAK2JAK3JAK1HDAC1TYK2 | |
| SCHEMBL13253337 | 0.83 | JAK2 (0.72) | JAK2JAK3JAK1HDAC1TYK2 | |
| SCHEMBL16446383 | 0.79 | JAK2 (1.00) | JAK2JAK3JAK1HDAC1TYK2 | |
| SCHEMBL13253260 | 0.79 | JAK2 (0.80) | JAK2JAK3JAK1HDAC1TYK2 | |
| SCHEMBL16156897 | 0.79 | JAK2 (0.81) | JAK2JAK3JAK1HDAC1TYK2 | |
| SCHEMBL13253906 | 0.79 | JAK2 (0.79) | JAK2JAK3JAK1HDAC1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100197671-A1 | PHENYL AMINO PYRIMIDINE COMPOUNDS AND USES THEREOF | GLAXOSMITHKLINE LLC | 2010-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197671-A1 | PHENYL AMINO PYRIMIDINE COMPOUNDS AND USES THEREOF | JAK2, JAK1, JAK3 | JAK2 1/4885JAK3 3/4885JAK1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.