Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.61 |
| ▸ | BTK | Q06187 | 2/20 | 0.61 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.61 |
| ▸ | AURKA | O14965 | 2/20 | 0.61 |
| ▸ | ABL1 | P00519 | 2/20 | 0.61 |
| ▸ | EGFR | P00533 | 2/20 | 0.61 |
| ▸ | FYN | P06241 | 2/20 | 0.61 |
| ▸ | LYN | P07948 | 2/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.61 |
| ▸ | FLT3 | P36888 | 2/20 | 0.61 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.61 |
| ▸ | STK3 | Q13188 | 2/20 | 0.61 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.61 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.61 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.61 |
| ▸ | PLK4 | O00444 | 2/20 | 0.61 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.61 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.61 |
| ▸ | STK16 | O75716 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL645958 | 0.93 | CHEK1 (0.70) | TBK1BTKCHEK1AURKAABL1 | |
| SCHEMBL646253 | 0.86 | FYN (0.71) | TBK1BTKCHEK1AURKAABL1 | |
| SCHEMBL2121727 | 0.85 | PLK4 (0.70) | TBK1BTKCHEK1AURKAABL1 | |
| SCHEMBL644606 | 0.84 | PLK4 (0.69) | TBK1BTKCHEK1AURKAABL1 | |
| SCHEMBL13330071 | 0.84 | CHEK1 (0.53) | TBK1BTKCHEK1AURKAABL1 | |
| SCHEMBL644980 | 0.84 | MAP3K11 (0.68) | TBK1BTKCHEK1AURKAABL1 | |
| SCHEMBL2121304 | 0.83 | BTK (0.68) | TBK1BTKCHEK1AURKAABL1 | |
| SCHEMBL2123073 | 0.83 | BTK (0.68) | TBK1BTKCHEK1AURKAABL1 | |
| SCHEMBL2123032 | 0.83 | BTK (0.68) | TBK1BTKCHEK1AURKAABL1 | |
| SCHEMBL644444 | 0.83 | ABL1 (0.68) | TBK1BTKCHEK1AURKAABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318939-B2 | Kinase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-11-27 | — | — | US | disclosed |
| US-8318939-B2 | Kinase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-11-27 | — | — | US | disclosed |
| US-20100190816-A1 | KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-07-29 | — | — | US | disclosed |
| US-20100190816-A1 | KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190816-A1 | KINASE INHIBITORS | MAP3K20, MAP3K19, MAP3K1 | TBK1 361/4885BTK 112/4885CHEK1 57/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.