Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 2/20 | 0.38 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | TDO2 | P48775 | 2/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
| ▸ | EIF4E | P06730 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6842879 | 0.84 | GSK3B (0.41) | CDC7DBF4EIF4EGSK3BMAPK14 | |
| SCHEMBL952177 | 0.81 | CDC7 (0.47) | PIM1CDC7DBF4PIM3PIM2 | |
| SCHEMBL16938042 | 0.72 | GSK3B (0.42) | CDC7DBF4EIF4EGSK3BMAPK14 | |
| SCHEMBL558935 | 0.71 | ALOX5AP (0.55) | DYRK1APIM1CDK9DYRK2DYRK1B | |
| SCHEMBL6842878 | 0.69 | MAPK14 (0.49) | CDC7DBF4GSK3BMAPK14 | |
| SCHEMBL952381 | 0.68 | ADORA2A (0.44) | CDC7DBF4IDO1MAPK14 | |
| SCHEMBL12947666 | 0.66 | PIK3C3 (0.44) | CDC7DBF4GSK3BMAPK14CYP3A4 | |
| SCHEMBL16937936 | 0.66 | CDC7 (0.49) | DYRK1APIM1CDC7DBF4PIM3 | |
| SCHEMBL954822 | 0.65 | MAPK14 (0.45) | GSK3BMAPK14 | |
| SCHEMBL16937935 | 0.65 | MAPK14 (0.42) | CDC7DBF4MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010090716-A1 | HETEROARYLS AND THEIR USE AS PI3K INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-08-12 | — | — | WO | disclosed |