Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 3/20 | 0.38 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.33 |
| ▸ | KRAS | P01116 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13257053 | 0.90 | PIM1 (0.34) | CDC7DBF4PIM1PIM3PIM2 | |
| SCHEMBL6842848 | 0.83 | PIK3C3 (0.39) | CDC7DBF4PIK3C3MAPK14 | |
| SCHEMBL6842852 | 0.81 | CDC7 (0.43) | CDC7DBF4PIM1PIM3PIM2 | |
| SCHEMBL16938035 | 0.81 | CDC7 (0.42) | CDC7DBF4PIM1PIM3PIM2 | |
| SCHEMBL16938030 | 0.76 | MAPK14 (0.34) | CDC7DBF4MAPK14 | |
| SCHEMBL16937936 | 0.76 | CDC7 (0.49) | CDC7DBF4PIM1PIM3PIM2 | |
| SCHEMBL16938036 | 0.76 | MAPK14 (0.42) | CDC7DBF4PIK3C3MAPK14 | |
| SCHEMBL6842826 | 0.76 | MAPK14 (0.33) | MAPK14 | |
| SCHEMBL6842830 | 0.72 | PIK3C3 (0.42) | CDC7DBF4PIK3C3MAPK14 | |
| SCHEMBL16938031 | 0.71 | MAPK14 (0.43) | CDC7DBF4PIK3C3MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010090716-A1 | HETEROARYLS AND THEIR USE AS PI3K INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-08-12 | — | — | WO | disclosed |