Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 18/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL604422 | 0.91 | GPBAR1 (0.51) | GPBAR1 | |
| SCHEMBL604486 | 0.87 | GPBAR1 (0.46) | GPBAR1 | |
| SCHEMBL602688 | 0.86 | GPBAR1 (0.60) | GPBAR1NR1H4 | |
| SCHEMBL604880 | 0.86 | GPBAR1 (0.47) | GPBAR1 | |
| SCHEMBL604934 | 0.83 | GPBAR1 (0.52) | GPBAR1NR1H4 | |
| SCHEMBL601541 | 0.81 | GPBAR1 (0.53) | GPBAR1NR1H4 | |
| SCHEMBL605169 | 0.80 | GPBAR1 (0.61) | GPBAR1NR1H4 | |
| SCHEMBL601929 | 0.80 | GPBAR1 (0.50) | GPBAR1MEN1KMT2A | |
| SCHEMBL603761 | 0.80 | GPBAR1 (0.52) | GPBAR1NR1H4 | |
| SCHEMBL602151 | 0.79 | GPBAR1 (0.47) | GPBAR1NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010093845-A1 | TRIAZOLE AND IMIDAZOLE DERIVATIVES FOR USE AS TGR5 AGONISTS IN THE TREATMENT OF DIABETES AND OBESITY | EXELIXIS, INC. (US) | 2010-08-19 | — | — | WO | disclosed |