Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.53 |
| ▸ | BACE1 | P56817 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 3/20 | 0.41 |
| ▸ | JAK1 | P23458 | 3/20 | 0.41 |
| ▸ | TYK2 | P29597 | 3/20 | 0.41 |
| ▸ | JAK3 | P52333 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MAT2A | P31153 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7885451 | 0.87 | KMT2A (0.62) | KMT2ANUDT1BACE1KDM4ETBXA2R | |
| SCHEMBL10176976 | 0.87 | KMT2A (0.66) | KMT2ANUDT1BACE1KDM4ETBXA2R | |
| SCHEMBL27866490 | 0.80 | KMT2A (0.53) | KMT2ANUDT1BACE1KDM4ETBXA2R | |
| SCHEMBL7260548 | 0.78 | KMT2A (1.00) | KMT2ANUDT1BACE1KDM4EHTT | |
| SCHEMBL10177398 | 0.77 | MAPT (0.51) | KMT2ANUDT1BACE1TBXA2RHDAC1 | |
| SCHEMBL23100636 | 0.76 | BACE1 (0.63) | KMT2ANUDT1BACE1KDM4ETBXA2R | |
| SCHEMBL11201306 | 0.76 | BACE1 (0.67) | KMT2ANUDT1BACE1TBXA2RHDAC1 | |
| SCHEMBL418587 | 0.75 | GNRHR (0.50) | KMT2AKDM4ETBXA2RSMN1; SMN2HTT | |
| Hydrochloric Acid SCHEMBL11385604 | 0.74 | PDE10A (0.50) | KMT2ANUDT1BACE1KDM4EJAK2 | |
| Hydrochloric Acid SCHEMBL11385601 | 0.74 | PDE10A (0.50) | KMT2ANUDT1BACE1KDM4EJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010093425-A1 | HISTAMINE H3 INVERSE AGONISTS AND ANTAGONISTS AND METHODS OF USE THEREOF | SEPRACOR INC. (US) | 2010-08-19 | — | — | WO | disclosed |