Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | HSPA5 | P11021 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.37 |
| ▸ | CDC25B | P30305 | 6/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.36 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.36 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.36 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.36 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.36 |
| ▸ | GJB2 | P29033 | 2/20 | 0.35 |
| ▸ | TACR2 | P21452 | 2/20 | 0.35 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.34 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | NT5E | P21589 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12261243 | 0.92 | PDE2A (0.42) | PDE2AHSPA5PTPN1CDC25BHTR1A | |
| SCHEMBL12261311 | 0.92 | PDE2A (0.42) | PDE2AHSPA5PTPN1CDC25BHTR1A | |
| SCHEMBL12261148 | 0.79 | HSPA5 (0.40) | PDE2AHSPA5PTPN1CDC25BHTR1A | |
| SCHEMBL21137107 | 0.77 | PDE2A (0.45) | PDE2AHSPA5PTPN1CDC25BHTR1A | |
| SCHEMBL26812522 | 0.77 | PDE2A (0.45) | PDE2AHSPA5PTPN1CDC25BHTR1A | |
| SCHEMBL19644579 | 0.75 | PDE2A (0.51) | PDE2AHSPA5PTPN1CDC25BHTR1A | |
| SCHEMBL12260860 | 0.75 | HSPA5 (0.37) | PDE2AHSPA5PTPN1CDC25BHTR1A | |
| SCHEMBL12310816 | 0.72 | HSPA5 (0.31) | HSPA5 | |
| SCHEMBL17465437 | 0.70 | PDE2A (0.33) | PDE2AHSPA5 | |
| SCHEMBL12260861 | 0.70 | HSPA5 (0.37) | PDE2AHSPA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140170148-A1 | BISPECIFIC ANTIBODIES AGAINST HER2 | GENMAB A/S (DK) | 2014-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140170148-A1 | BISPECIFIC ANTIBODIES AGAINST HER2 | ERBB2, EGFR, ERBB3 | PDE2A 4850/4885HSPA5 2329/4885PTPN1 846/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.