Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 11/20 | 0.53 |
| ▸ | LCK | P06239 | 5/20 | 0.52 |
| ▸ | CSF1R | P07333 | 5/20 | 0.52 |
| ▸ | EGFR | P00533 | 4/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.52 |
| ▸ | KIT | P10721 | 9/20 | 0.50 |
| ▸ | BCR | P11274 | 5/20 | 0.50 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.50 |
| ▸ | ABL2 | P42684 | 5/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.49 |
| ▸ | FYN | P06241 | 2/20 | 0.49 |
| ▸ | LYN | P07948 | 2/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.49 |
| ▸ | FGR | P09769 | 2/20 | 0.49 |
| ▸ | SRC | P12931 | 2/20 | 0.49 |
| ▸ | BRAF | P15056 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15859835 | 0.92 | ABL1 (0.51) | ABL1LCKCSF1REGFRMAPK14 | |
| SCHEMBL15859886 | 0.91 | ABL1 (0.51) | ABL1LCKCSF1REGFRMAPK14 | |
| SCHEMBL15859833 | 0.91 | ABL1 (0.50) | ABL1LCKCSF1REGFRMAPK14 | |
| SCHEMBL3808468 | 0.90 | ABL1 (0.58) | ABL1LCKCSF1REGFRMAPK14 | |
| SCHEMBL28036042 | 0.85 | ABL1 (0.49) | ABL1LCKCSF1REGFRMAPK14 | |
| SCHEMBL13261072 | 0.83 | IKBKE (0.44) | ABL1LCKCSF1REGFRMAPK14 | |
| SCHEMBL15860017 | 0.83 | BRAF (0.49) | ABL1LCKEGFRKITBCR | |
| SCHEMBL15859869 | 0.82 | KIT (0.53) | ABL1LCKEGFRKITBCR | |
| SCHEMBL15860018 | 0.82 | ABL1 (0.57) | ABL1LCKEGFRKITBCR | |
| SCHEMBL15859946 | 0.81 | ABL1 (0.51) | ABL1LCKCSF1REGFRMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396325-B1 | DERIVATIVES OF AZAINDOLES AS INHIBITORS OF PROTEIN KINASES ABL AND SRC | ORIBASE PHARMA (FR) | 2015-04-01 | — | — | EP | disclosed |
| WO-2010092489-A1 | DERIVATIVES OF AZAINDOLES AS INHIBITORS OF PROTEIN KINASES ABL AND SRC | NOVA DECISION (FR) | 2010-08-19 | — | — | WO | disclosed |